Muhammad Zia Karim
Papers
1
Total Citations
49
H-Index
1
About
Muhammad Zia Karim is a leading researcher in intervertebral disc (IVD) biology, with a focus on degenerative disc disease. His work bridges proteomics and biomechanics to uncover the molecular and mechanical underpinnings of spinal degeneration. In his highly cited 2015 study, Karim employed iTRAQ proteomic methods alongside biomechanical testing to characterize the secretome of nucleus pulposus cells in chondrodystrophic and non-chondrodystrophic canine models. This work provided critical insights into how breed-specific differences in disc composition and mechanical properties contribute to early-onset degeneration. With nearly 50 citations, the study has become a foundational reference for comparative models of disc disease. Karim’s contributions are notable for integrating advanced quantitative proteomics with functional tissue mechanics, offering a systems-level view of disc pathophysiology. His research has important implications for identifying therapeutic targets and developing translational models for human spinal disorders, making him a key figure in orthopaedic and regenerative medicine research.
Research Focus
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Top Papers
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