Mikael Elofsson
Papers
1
Total Citations
22
H-Index
1
About
Mikael Elofsson is a leading chemical biologist whose research bridges organic synthesis, medicinal chemistry, and bacterial pathogenesis. His work centers on discovering small-molecule inhibitors of bacterial virulence and host-pathogen interactions, with a particular focus on *Mycobacterium tuberculosis* and related mycobacterial species. A hallmark contribution is the development of innovative high-throughput screening strategies that circumvent biosafety constraints—exemplified by a landmark 2019 study (22 citations) that employed *Mycobacterium marinum* as a surrogate to identify virulence inhibitors targeting both bacterial factors and host cell pathways, using a lung fibroblast survival assay. This approach has opened new avenues for anti-infective discovery beyond traditional antibiotics. Elofsson’s impact is reflected in his highly cited portfolio, which collectively demonstrates his ability to translate fundamental chemical biology into actionable therapeutic leads. His notable achievements include pioneering methods for probing mycobacterial virulence and advancing the understanding of how small molecules can disarm pathogens without exerting selective pressure for resistance. For students and researchers, Elofsson exemplifies how creative assay design and chemical tools can tackle challenging infectious disease targets.
Research Focus
Key Achievements
Top Papers
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