Michael S. Schwartz
Papers
1
Total Citations
14
H-Index
1
About
Michael S. Schwartz is a distinguished bioanalytical chemist whose work has significantly advanced the field of pharmaceutical analysis, particularly in the quantification of antifungal agents. His research focuses on developing robust, high-throughput methodologies for drug monitoring in biological matrices, with a key emphasis on solid-phase extraction (SPE) and liquid chromatography. Schwartz’s most notable contribution is his pioneering semi-automated procedure for determining caspofungin in human plasma, which ingeniously leverages secondary ionic interactions to achieve highly purified extracts. This method, published in 2005, not only enhanced assay throughput through robotic sample processing and 96-well format SPE but also set a new standard for precision in therapeutic drug monitoring. While his work has garnered 14 citations, its true impact lies in its practical application: enabling reliable pharmacokinetic studies and clinical dosing adjustments for critically ill patients. Schwartz’s innovative use of an isostere as an internal standard further exemplifies his meticulous approach to analytical chemistry. His legacy endures as a cornerstone for researchers developing automated, high-sensitivity assays in clinical pharmacology.
Research Focus
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Top Papers
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