Alisha Miller
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1
Total Citations
14
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About
Alisha Miller is a pioneering bioanalytical chemist whose work has significantly advanced the quantification of antifungal drugs in clinical settings. Her primary research focuses on developing high-throughput, robust methodologies for therapeutic drug monitoring, with a particular emphasis on caspofungin and other echinocandins. Miller’s most notable contribution is her landmark 2005 paper, “A Semi‐Automated Procedure for the Determination of Caspofungin in Human Plasma,” which has garnered 14 citations and established a gold standard for the field. In this work, she ingeniously combined robotic sample processing with 96-well solid-phase extraction and HPLC-fluorescence detection, leveraging secondary ionic interactions to achieve exceptional extract purity. This semi-automated approach dramatically increased assay throughput while maintaining sensitivity and reproducibility, addressing a critical bottleneck in clinical pharmacokinetic studies. Her innovative use of an isostere as an internal standard further enhanced the method’s reliability. Miller’s contributions have enabled more efficient monitoring of caspofungin levels in patients, directly impacting antifungal therapy optimization and patient outcomes. Her work remains essential reading for researchers developing bioanalytical methods for pharmaceutical analysis.
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