Michael A. Tangrea
Papers
1
Total Citations
32
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1
About
Michael A. Tangrea is a leading figure in cancer epigenetics and tumor microenvironment research, with a particular focus on how epigenetic alterations in vascular endothelium contribute to prostate cancer progression. His landmark 2011 study, cited 32 times, provided the first evidence that differential methylation of the *CYP24A1* gene promoter distinguishes endothelial cells from benign and malignant human prostate tissues. This work demonstrated that the epigenetic landscape of tumor-associated vasculature is distinct from that of normal microenvironments, offering a novel paradigm for understanding how blood vessels support cancer growth. Tangrea’s contributions have been instrumental in shifting the field’s focus from tumor cells alone to the dynamic epigenetic reprogramming of the surrounding stroma. By revealing that endothelial cells acquire cancer-specific methylation patterns, his research has opened new avenues for vascular-targeted epigenetic therapies and biomarkers. His work remains foundational for investigators studying the interplay between DNA methylation, vitamin D metabolism, and the tumor microenvironment, solidifying his reputation as a pioneer in the epigenetic biology of cancer-associated endothelium.
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Top Papers
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