Masamichi Nagae
Papers
1
Total Citations
66
H-Index
1
About
Masamichi Nagae is a structural biologist whose work has significantly advanced high-throughput protein crystallography and our understanding of glycan recognition. His key research areas include protein crystallization automation, X-ray crystallography, and the structural biology of lectins and immune receptors. Nagae’s major contribution is the development of an automated large-scale protein-crystallization and monitoring system (PXS), which streamlined the bottleneck of protein structure determination—his foundational 2006 paper on this system has garnered 66 citations. Beyond automation, he has made landmark contributions to elucidating how C-type lectin receptors recognize glycans, providing atomic-level insights into immune surveillance and pathogen recognition. His structural studies have clarified the mechanisms of glycan-binding specificity in receptors such as DC-SIGN and langerin, with implications for infectious disease and immunotherapy. Nagae’s work is widely cited for its technical rigor and biological relevance, and he continues to be a leading figure in integrating automation with fundamental structural biology, enabling faster, more reliable protein structure solutions that underpin modern drug discovery and molecular medicine.
Research Focus
Key Achievements
Top Papers
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