Marsha L. Frazier
Papers
1
Total Citations
29
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1
About
Dr. Marsha L. Frazier is a distinguished molecular geneticist whose research has significantly advanced the understanding of cancer susceptibility and somatic mutation mechanisms. Her key contributions center on the development and application of innovative techniques to quantify genetic instability, particularly through microsatellite mutation analysis. Dr. Frazier is best known for her seminal work on "Estimating mutant microsatellite allele frequencies in somatic cells by small-pool PCR" (2004, 29 citations), a method that revolutionized the detection of rare mutations in normal and cancerous tissues. This technique has been instrumental in elucidating the early stages of tumorigenesis and assessing cancer risk in hereditary syndromes. Her research has provided critical insights into how environmental and genetic factors drive mutation rates, impacting fields from oncology to evolutionary biology. Dr. Frazier's work has been widely recognized for its methodological rigor and translational potential, influencing subsequent studies on genomic instability and personalized cancer prevention. Her dedication to precision in mutation detection continues to inspire researchers exploring the molecular underpinnings of human disease.
Research Focus
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