Atousa Maleki
Papers
1
Total Citations
29
H-Index
1
About
Atousa Maleki is a molecular geneticist whose research focuses on the mechanisms of genomic instability, particularly through the lens of microsatellite mutations. Her most-cited work, "Estimating mutant microsatellite allele frequencies in somatic cells by small-pool PCR" (2004, 29 citations), introduced a highly sensitive method for detecting rare somatic mutations. This technique allows researchers to quantify microsatellite instability at the single-cell level, providing critical insights into how these mutations accumulate in normal and diseased tissues, including cancer. By enabling precise measurement of mutation frequencies, Maleki’s contribution has advanced the understanding of DNA replication errors and their role in tumorigenesis. Her work is foundational for studies on genetic mosaicism and aging-related genomic changes, offering a robust tool for investigating the earliest stages of carcinogenesis. Though her citation count reflects a specialized niche, the impact of her methodology endures in fields from evolutionary biology to clinical diagnostics, underscoring her role in refining the tools used to explore the dynamic landscape of the human genome.
Research Focus
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Top Papers
- 1