Marco Lolaico
Papers
1
Total Citations
65
H-Index
1
About
Marco Lolaico is a pioneering researcher at the intersection of DNA nanotechnology and synthetic biology, whose work focuses on engineering intelligent molecular machines for targeted therapeutic intervention. His most notable contribution is the development of a DNA robotic switch capable of regulated, autonomous display of cytotoxic ligand nanopatterns on cell membranes. This groundbreaking system, published in 2024 and already garnering 65 citations, addresses a critical challenge in cancer therapy: how to selectively trigger apoptosis in tumour cells by clustering death receptors while sparing healthy tissue. By designing a stimuli-responsive DNA nanodevice that only presents its lethal ligand patterns in the presence of specific cancer-associated molecular cues, Lolaico has created a programmable "kill switch" at the nanoscale. This work represents a significant leap forward in the field of DNA robotics, moving beyond proof-of-concept demonstrations toward functional, disease-responsive nanomachines. His research elegantly combines principles of DNA origami, molecular computing, and cell biology, offering a powerful platform for smart drug delivery systems. Lolaico’s achievements mark him as a rising leader in the development of autonomous nanotherapeutics with the potential to revolutionize precision oncology.
Research Focus
Key Achievements
Top Papers
- 1