Lynne Ohler
Papers
1
Total Citations
90
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1
About
Dr. Lynne Ohler is a pioneering researcher in the field of genomic analysis, with a primary focus on the development of high-throughput methods for genetic marker detection. Her most notable contribution is the landmark 1999 paper, "Single nucleotide polymorphism determination using primer extension and time-of-flight mass spectrometry," which has garnered over 90 citations. This work revolutionized the identification of single nucleotide polymorphisms (SNPs)—the most abundant genetic variations in the human genome—by introducing a rapid, accurate, and scalable technique. By combining primer extension with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), Ohler overcame the laborious and time-consuming limitations of conventional SNP detection methods. Her innovation has had a profound impact on identity testing, genome mapping, and medical diagnostics, enabling large-scale genetic studies that were previously impractical. Ohler's research continues to influence the fields of molecular biology and personalized medicine, providing essential tools for understanding genetic diversity and disease susceptibility. Her work stands as a cornerstone in the evolution of modern genomic technologies.
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