Lucie Vizor
Papers
2
Total Citations
75
H-Index
2
About
Lucie Vizor’s research lies at the intersection of neurogenetics and developmental biology, with a primary focus on understanding the genetic underpinnings of cerebellar degeneration and motor dysfunction. Her most influential work centers on the “robotic mouse,” a mutant model characterized by a jerky, ataxic gait and adult-onset Purkinje cell loss in the cerebellum, alongside cataracts. In her landmark 2003 study, which has garnered 72 citations, Vizor identified a mutation in the *Af4* gene as the predicted cause of this striking phenotype. This discovery provided critical insight into region-specific neuronal vulnerability and the genetic pathways linking cerebellar ataxia to ocular defects. Her subsequent functional studies, though less cited, further explored the role of Af4 in neural development and disease. Vizor’s contributions have been instrumental in advancing the use of chemical mutagenesis screens to model human neurodegenerative conditions, offering a valuable platform for exploring therapeutic targets. Her work remains a key reference for researchers investigating inherited ataxias and the molecular mechanisms of Purkinje cell survival.
Research Focus
Key Achievements
Top Papers
- 1
- 2Functional studies of Af4 in the robotic mouse.3 citations · 2003