Lingru Xue
Papers
1
Total Citations
35
H-Index
1
About
Dr. Lingru Xue is a pioneering surgical oncologist whose research focuses on intraoperative molecular imaging and fluorescence-guided surgery for prostate cancer. Her major contribution lies in advancing the clinical translation of prostate-specific membrane antigen (PSMA)-targeted near-infrared fluorescent agents to improve surgical precision. Dr. Xue led the landmark first-in-human evaluation of IS-002, a novel fluorescent small molecule designed to illuminate microscopic cancer deposits during robotic-assisted prostatectomy. This groundbreaking work, published in 2023 and already garnering 35 citations, demonstrated the safety, pharmacokinetics, and exploratory efficacy of real-time fluorescence guidance in high-risk prostate cancer patients—a population where incomplete resection often leads to recurrence. By enabling surgeons to visualize otherwise undetectable tumor margins and extraprostatic extensions, her research directly addresses a critical unmet need in urologic oncology. Dr. Xue’s contributions bridge the gap between molecular imaging probes and clinical application, offering a transformative approach to achieving complete oncologic resections while preserving healthy tissue. Her work has been recognized for its potential to reduce positive surgical margins and improve outcomes in men with high-risk prostate cancer, positioning her at the forefront of precision surgery.
Research Focus
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Top Papers
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