Letha J. Sooter
Papers
1
Total Citations
22
H-Index
1
About
Letha J. Sooter is a pioneering researcher in the field of nucleic acid biochemistry, with a primary focus on the development and automation of aptamer and deoxyribozyme selection technologies. Her most-cited work, "Toward Automated Nucleic Acid Enzyme Selection" (2001, 22 citations), represents a landmark contribution to the field by demonstrating the successful automation of aptamer selection using a Biomek 2000 workstation. This breakthrough enabled the isolation of binding species with nanomolar affinities from highly diverse nucleic acid populations, significantly accelerating the discovery process for functional nucleic acids. Sooter’s work also extended to automating deoxyribozyme ligase selections, showcasing her innovative approach to streamlining complex molecular evolution experiments. Her contributions have had a lasting impact on the development of nucleic acid-based tools for diagnostics, therapeutics, and biosensing. By reducing the manual labor and increasing the throughput of selection experiments, Sooter’s research has paved the way for more efficient and scalable production of high-affinity aptamers and catalytic nucleic acids, making her a key figure in advancing automated molecular selection methodologies.
Research Focus
Key Achievements
Top Papers
- 1Toward Automated Nucleic Acid Enzyme Selection22 citations · 2001