Julie Clements
Papers
1
Total Citations
30
H-Index
1
About
Julie Clements is a leading researcher in genetic toxicology, with a focus on developing innovative methods for assessing the genotoxicity of complex aerosols and gaseous mixtures, particularly mainstream cigarette smoke. Her most-cited work, "A method for assessment of the genotoxicity of mainstream cigarette-smoke by use of the bacterial reverse-mutation assay and an aerosol-based exposure system" (2014, 30 citations), addresses a critical gap in toxicological testing: the lack of widely accepted protocols for evaluating the mutagenic potential of whole smoke. By adapting the standard bacterial reverse-mutation (Ames) assay to an aerosol-based exposure system, Clements pioneered a more physiologically relevant approach, enabling direct testing of cigarette smoke without the confounding effects of particle trapping or solvent extraction. This contribution has been instrumental in advancing regulatory science, offering a practical tool for tobacco product evaluation and harm reduction research. Her work underscores the importance of bridging traditional in vitro assays with real-world exposure scenarios, marking her as a key figure in the evolution of genetic toxicology testing methodologies.
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- 1