Juan Etxebarria
Papers
1
Total Citations
68
H-Index
1
About
Juan Etxebarria is a leading figure in chemical glycobiology, whose work has fundamentally advanced the study of complex carbohydrates. His primary research focuses on the chemoenzymatic synthesis of N-glycans and the development of glycan microarrays, powerful tools for deciphering the roles of sugars in biological recognition. Etxebarria’s major contribution is a groundbreaking modular strategy that combines chemical synthesis with on-chip nanoscale enzymatic glycosylation. This approach, detailed in his highly cited 2010 paper (68 citations), enabled the first-ever construction of a focused microarray of synthetic N-glycans. By chemically synthesizing core structures and then enzymatically extending them directly on a glass surface, his method bypassed the traditional challenges of isolating pure, complex glycans from natural sources. This innovation has provided researchers with a versatile platform to probe protein-glycan interactions, with direct implications for understanding infection, immunity, and cancer. His work stands as a cornerstone in the field, offering a practical and scalable route to the high-throughput analysis of the glycome.
Research Focus
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