Joshua H. Mo
Papers
1
Total Citations
2
H-Index
1
About
Joshua H. Mo is a structural biologist whose work bridges computational prediction and experimental validation to solve challenging protein crystallization problems. His research focuses on large coiled-coil containing proteins—a class notoriously difficult to crystallize due to their elongated shape and aggregation-prone nature. Mo’s key contribution lies in developing integrated strategies that combine wet-lab techniques with dry-lab computational approaches to guide crystallization efforts. His most cited work, "Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins" (2017), has garnered 2 citations and provides a practical framework for overcoming the unique obstacles these proteins present. By systematically addressing the physical properties that make coiled-coil domains recalcitrant to structural determination, Mo has helped advance the toolkit available for studying these widespread and functionally important protein architectures. His approach offers valuable guidance for researchers tackling similarly difficult crystallization targets, demonstrating that even traditionally "difficult" proteins can yield to thoughtful, multi-pronged strategies.
Research Focus
Key Achievements
Top Papers
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