Andrew P. VanDemark
Papers
2
Total Citations
4
H-Index
2
About
Andrew P. VanDemark is a structural biologist whose research focuses on the crystallization and structural characterization of complex proteins, with particular emphasis on coiled-coil containing proteins. His work bridges computational and experimental approaches, integrating both wet and dry laboratory techniques to overcome longstanding challenges in protein crystallography. VanDemark's most recognized contribution addresses a fundamental bottleneck in structural biology: obtaining high-quality crystals from proteins that are notoriously difficult to work with. Coiled-coil domains, despite their ubiquity throughout nature, present significant technical hurdles due to their physical properties and strong tendency to aggregate. His methodological framework for guiding the crystallization of these large, complex proteins represents a meaningful advance for researchers tackling similar structural challenges. By combining computational prediction tools with refined experimental protocols, VanDemark has helped establish more systematic strategies for approaching what has traditionally been a largely trial-and-error process. His 2017 work in this area has accumulated citations reflecting its utility among structural biology and biochemistry communities. For students and researchers working with difficult protein targets, VanDemark's integrated approach offers both practical guidance and a conceptual model for how informatics and bench science can be productively combined to accelerate structural discovery.
Research Focus
Key Achievements
Top Papers
- 1
- 2