Jonathan P. Brennan
Papers
2
Total Citations
312
H-Index
2
About
Jonathan P. Brennan is a leading researcher in redox biology and cardiovascular proteomics, whose work has fundamentally advanced our understanding of how oxidative stress regulates protein function in the heart. His research focuses on the molecular mechanisms of reversible cysteine oxidation, particularly protein S-glutathiolation and disulfide bond formation, and their roles in cardiac physiology and disease. Brennan’s landmark 2004 study, cited over 188 times, pioneered the use of diagonal electrophoresis to map widespread intermolecular protein disulfide formation during cardiac oxidative stress, revealing a previously underappreciated layer of redox regulation. He further developed innovative tools, such as N,N-biotinyl glutathione disulfide, to specifically track S-glutathiolation events, a contribution that has garnered over 124 citations and become a standard approach in the field. By elucidating how post-translational modifications like S-nitrosylation and sulfenyl amide formation alter protein activity, Brennan has provided critical insights into the signaling pathways that protect or damage the heart under stress. His work is essential reading for students and researchers exploring redox signaling, proteomics, and the molecular basis of cardiovascular disease.
Research Focus
Key Achievements
Top Papers
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