J Miller
Papers
1
Total Citations
124
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1
About
J. Miller has made foundational contributions to redox biology, with a primary focus on the molecular mechanisms of protein S-glutathiolation—a reversible post-translational modification that occurs under oxidative stress. Their landmark 2005 paper, "The Utility of N,N-Biotinyl Glutathione Disulfide in the Study of Protein S-Glutathiolation," has garnered 124 citations and introduced a powerful tool for probing how elevated glutathione disulfide (GSSG) alters protein function during neurohormonal stimulation, metabolic shifts, and disease. This work illuminated how cells respond to increased oxidant loads, linking S-glutathiolation directly to signaling and pathology. Miller’s research has been instrumental in advancing our understanding of redox regulation, providing methodologies that enable precise detection of modified proteins. Their contributions have shaped how the field studies oxidative stress in cardiovascular, metabolic, and neurodegenerative contexts, making their work essential reading for students and researchers exploring the intersection of reactive oxygen species and cellular signaling.
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