Jon B. Toledo
Papers
1
Total Citations
62
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1
About
Jon B. Toledo is a leading researcher in the clinical neuroscience of Alzheimer’s disease, with a primary focus on improving the reliability and utility of fluid biomarkers for early diagnosis and longitudinal tracking. His most cited work, the 2012 study “Improved protocol for measurement of plasma β‐amyloid in longitudinal evaluation of Alzheimer's Disease Neuroimaging Initiative study patients,” directly tackled a critical bottleneck in the field: the high interassay variability of plasma β-amyloid measurements. By developing and validating a standardized protocol, Toledo’s research enabled more consistent, cross-center data interpretation, paving the way for meta-analyses and large-scale biomarker studies. This contribution has been cited over 60 times, reflecting its foundational role in advancing blood-based diagnostics. Beyond this, Toledo’s broader work integrates cerebrospinal fluid biomarkers, neuroimaging, and clinical phenotypes to refine the staging and subtyping of Alzheimer’s pathology. His efforts have helped bridge the gap between research settings and clinical application, making him a key figure in the push toward accessible, reliable biomarkers for dementia. For students and researchers, his work exemplifies how methodological rigor can unlock translational progress in neurodegenerative disease research.
Research Focus
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