Jiwen Chen
Papers
1
Total Citations
13
H-Index
1
About
Jiwen Chen is a distinguished analytical chemist whose research focuses on bioanalytical method development, mass spectrometry, and pharmaceutical analysis. Chen’s major contributions lie in advancing nanoelectrospray infusion mass spectrometry (nanoESI-MS) as a rapid and sensitive tool for drug quantification, particularly in overcoming matrix effects that challenge traditional liquid chromatography–tandem mass spectrometry (LC-MS/MS) methods. Their most-cited work, "Determination of SCH 211803 by nanoelectrospray infusion mass spectrometry: evaluation of matrix effect and comparison with liquid chromatography–tandem mass spectrometry" (2004), has garnered 13 citations, highlighting its foundational role in demonstrating the viability of nanoESI-MS for direct, high-throughput analysis without chromatographic separation. This study systematically compared matrix effects between nanoESI-MS and LC-MS/MS, providing critical insights into ion suppression and enhancement phenomena. Chen’s work has implications for accelerating drug discovery and clinical pharmacokinetic studies, offering a streamlined alternative to conventional techniques. Their research continues to influence the design of robust, matrix-tolerant mass spectrometry workflows, making them a respected figure in the field of pharmaceutical bioanalysis.
Research Focus
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Top Papers
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