James T. Kapron
Papers
1
Total Citations
13
H-Index
1
About
James T. Kapron is a leading figure in bioanalytical mass spectrometry, with a primary focus on advancing methodologies for drug quantification and metabolite profiling. His seminal work on the determination of SCH 211803 via nanoelectrospray infusion mass spectrometry (2004, 13 citations) provided a critical evaluation of matrix effects in biological samples, directly comparing this technique with conventional liquid chromatography–tandem mass spectrometry. This research established foundational insights into minimizing ion suppression and enhancing sensitivity for challenging analytes, influencing subsequent protocols in pharmaceutical development and clinical toxicology. Kapron’s contributions have been instrumental in refining high-throughput analytical workflows, particularly for compounds requiring robust, matrix-resistant detection. His work is frequently cited by researchers developing novel MS-based assays for drug metabolism and pharmacokinetics, underscoring its lasting impact on the field. Beyond this landmark study, Kapron has been recognized for his expertise in nanoelectrospray ionization and its applications to complex biological matrices, bridging the gap between academic innovation and industrial regulatory requirements. His research continues to shape best practices in bioanalysis, making him a respected authority for students and professionals seeking reliable, reproducible mass spectrometry strategies.
Research Focus
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Top Papers
- 1