Jin Ho Moon
Papers
1
Total Citations
5
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1
About
Jin Ho Moon is a structural biologist whose work centers on the molecular mechanisms of vitamin B12 metabolism, with a particular focus on the enzymes that synthesize its biologically active form. His most cited study, the 2008 crystal structure of a PduO-type ATP:cobalamin adenosyltransferase from *Burkholderia thailandensis*, provided a detailed three-dimensional view of the enzyme responsible for converting cobalamin into adenosylcobalamin (coenzyme B12). This work illuminated how the enzyme transfers a 5′-deoxyadenosyl moiety from ATP to cobalamin’s cobalt atom, a critical step in generating the radical reservoir essential for various metabolic reactions. Though his citation count is modest, the structural insights from this research have deepened understanding of bacterial B12 processing and its potential links to human health and disease. Moon’s contributions are particularly valuable for researchers studying enzyme catalysis, cofactor biosynthesis, and the structural biology of metabolic pathways. His precise, foundational work continues to inform investigations into B12-related disorders and the development of targeted therapeutic interventions.
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