Ae Kyung Park
Papers
1
Total Citations
5
H-Index
1
About
Ae Kyung Park is a structural biologist whose research centers on the molecular mechanisms of vitamin B12 metabolism and enzymatic catalysis. Her most-cited work, the 2008 paper detailing the crystal structure of a PduO-type ATP:cobalamin adenosyltransferase from *Burkholderia thailandensis*, represents a significant contribution to understanding how organisms convert cobalamin into its active coenzyme form, adenosylcobalamin. This enzyme catalyzes the transfer of a 5′-deoxyadenosyl moiety from ATP to cobalamin, creating a radical reservoir essential for various metabolic reactions. By elucidating this three-dimensional structure, Park provided critical insights into the enzyme's active site architecture and catalytic mechanism, advancing knowledge of B12-dependent processes in bacteria. While her citation count of 5 for this work reflects a specialized niche, the study's importance lies in its foundational contribution to structural enzymology and microbial metabolism. Park's research has implications for understanding bacterial pathogenesis and potential therapeutic targets, as *B. thailandensis* is a model organism for studying pathogenic *Burkholderia* species. Her work exemplifies how detailed structural characterization can illuminate fundamental biochemical pathways with relevance to human health and disease.
Research Focus
Key Achievements
Top Papers
- 1