Eun Hyuk Jang
Papers
1
Total Citations
5
H-Index
1
About
Eun Hyuk Jang is a structural biologist whose work has centered on the molecular machinery of vitamin B12 metabolism. His most-cited study, the 2008 paper on the crystal structure of a PduO-type ATP:cobalamin adenosyltransferase from *Burkholderia thailandensis*, provided critical insights into how organisms convert cobalamin into its active coenzyme form, adenosylcobalamin. This enzyme catalyzes the transfer of a 5′-deoxyadenosyl moiety from ATP to cobalamin’s cobalt atom, a key step that enables adenosylcobalamin to function as a radical reservoir in metabolic reactions. By elucidating this structure, Jang helped clarify the architecture and mechanism of a class of enzymes essential for bacterial and eukaryotic B12 utilization. Though his citation count (5) is modest, his contribution is foundational for researchers studying coenzyme B12 biosynthesis and its role in radical-based catalysis. Jang’s work exemplifies how detailed structural analysis can illuminate the fundamental biochemistry of vitamins and their cofactor functions, offering a stepping stone for further exploration into B12-dependent pathways and their biomedical implications.
Research Focus
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Top Papers
- 1