Jigneshkumar Patel
Papers
2
Total Citations
21
H-Index
2
About
Jigneshkumar Patel is a translational researcher whose work focuses on harnessing the immune system to fight human papillomavirus (HPV)-associated oropharyngeal cancer (HPVOPC), a disease now accounting for the majority of new oropharyngeal cancer diagnoses. His major contributions center on evaluating ADXS11-001, a novel live attenuated *Listeria monocytogenes*-based immunotherapy engineered to express the HPV E7 antigen. Patel’s pioneering “window of opportunity” clinical trial administered this immunotherapy prior to robotic surgery, demonstrating that it could enhance HPV-specific T cell immunity within the tumor microenvironment and peripheral blood. His most cited work (19 citations) established the feasibility and immunological rationale for this approach, while a subsequent study tracked changes in T cell receptor diversity, revealing how the therapy reshapes local and systemic immune repertoires. By directly targeting viral oncogenes expressed in HPVOPC, Patel’s research bridges fundamental immunology and surgical oncology, offering a promising path to improve outcomes for patients with this increasingly common cancer. His work underscores the potential of bacterial-based immunotherapies to turn a virus-driven malignancy into a treatable, immune-responsive disease.
Research Focus
Key Achievements
Top Papers
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