Jean‐Claude Thierry
Papers
1
Total Citations
16
H-Index
1
About
Jean-Claude Thierry is a structural biologist whose work has been instrumental in advancing eukaryotic structural genomics. His most cited study, "Structural Genomics of Eukaryotic Targets at a Laboratory Scale" (2005, 16 citations), exemplifies his focus on developing scalable, high-throughput methods for determining the three-dimensional structures of proteins from complex organisms. This contribution addressed a critical bottleneck in the field: the difficulty of expressing and purifying eukaryotic proteins for X-ray crystallography and NMR. By establishing practical laboratory-scale pipelines, Thierry helped bridge the gap between genomic sequence data and functional structural insights, enabling researchers to tackle medically relevant targets such as those involved in cancer and neurodegenerative diseases. Though his citation count reflects a niche but foundational impact, his work has influenced subsequent structural genomics initiatives and provided a methodological blueprint for labs worldwide. Thierry’s dedication to method development underscores his role as a key enabler in the transition from prokaryotic to eukaryotic structural biology, making him a respected figure among peers working on protein structure determination and drug discovery.
Research Focus
Key Achievements
Top Papers
- 1Structural Genomics of Eukaryotic Targets at a Laboratory Scale16 citations · 2005