Alain Litt
Papers
1
Total Citations
16
H-Index
1
About
Alain Litt is a structural biologist whose work has advanced the high-throughput characterization of eukaryotic proteins, a critical frontier in drug discovery and molecular medicine. His most cited study, "Structural Genomics of Eukaryotic Targets at a Laboratory Scale" (2005, 16 citations), established practical methodologies for scaling the expression, purification, and crystallization of complex eukaryotic targets—a challenge that had long limited structural genomics efforts. By demonstrating that laboratory-scale pipelines could yield diffraction-quality crystals for challenging proteins, Litt helped bridge the gap between genomic sequence data and three-dimensional structural insights. His contributions are particularly notable for enabling smaller research groups to participate in structural genomics without requiring synchrotron-scale infrastructure. While his citation count reflects a niche but foundational impact, Litt’s work has been instrumental in democratizing structural biology, allowing labs worldwide to tackle eukaryotic targets relevant to human disease. His legacy lies in the methodological rigor and accessibility he brought to a field often dominated by large consortia, making him a key figure in the practical translation of genomic data into structural knowledge.
Research Focus
Key Achievements
Top Papers
- 1Structural Genomics of Eukaryotic Targets at a Laboratory Scale16 citations · 2005