Jayne Marasa
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1
Total Citations
69
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1
About
Jayne Marasa is a neuroscientist whose research focuses on the molecular mechanisms of axon degeneration—a critical, self-destruction program underlying nerve damage in injury and disease. Her landmark 2011 study, cited 69 times, pioneered an innovative approach by combining robotic liquid handling with automated microscopy and image analysis to screen for novel regulators of this process. This work uncovered unexpected roles for IκB kinase and glycogen synthase kinase 3 in axonal breakdown, revealing that axon degeneration is an active, evolutionarily conserved pathway distinct from programmed cell death. By developing high-throughput, image-based screening methods, Marasa has provided powerful tools to dissect the signaling networks that govern neuronal integrity. Her contributions have significant implications for understanding neurodegenerative conditions and traumatic nerve injuries, where preventing axon loss could preserve function. Marasa’s research exemplifies how integrating automation and quantitative imaging can transform our understanding of fundamental neurobiological processes, opening new avenues for therapeutic intervention.
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