Jane Niederer
Papers
1
Total Citations
18
H-Index
1
About
Dr. Jane Niederer is a pioneering surgical oncologist whose research centers on molecular imaging and fluorescence-guided surgery for prostate cancer. Her landmark contribution is the first-in-human study of the PSMA-targeted minibody IR800-IAB2M, a novel agent that enables real-time, molecularly targeted intraoperative visualization of prostate cancer during radical prostatectomy. This work, published in 2024 and already garnering 18 citations, represents a paradigm shift in surgical precision—allowing surgeons to distinguish malignant tissue from healthy anatomy at a microscopic level during robot-assisted laparoscopic procedures. By conjugating a humanized PSMA minibody to the IRDye 800CW fluorophore, Dr. Niederer has addressed critical challenges in prostate cancer surgery, including incomplete resection and positive surgical margins. Her translational approach bridges preclinical development and clinical application, positioning her at the forefront of theranostics and image-guided oncology. This breakthrough not only demonstrates the feasibility of targeted fluorescence guidance in urologic surgery but also establishes a framework for expanding molecularly targeted intraoperative imaging to other solid tumors. Dr. Niederer’s work is rapidly shaping the future of precision surgery.
Research Focus
Key Achievements
Top Papers
- 1