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About

Alessandro Mascioni is a pioneering researcher in molecular imaging and surgical oncology, with a primary focus on prostate cancer. His work centers on developing novel targeted imaging agents to improve intraoperative guidance during radical prostatectomy. Mascioni’s major contribution is the first-in-human study of the PSMA Minibody IR800-IAB2M, a humanized, fluorescently labeled molecule designed to bind prostate-specific membrane antigen (PSMA) for real-time visualization of cancerous tissue during robot-assisted laparoscopic surgery. This groundbreaking study, published in 2024 and already cited 18 times, demonstrates the feasibility of molecularly targeted fluorescence guidance to enhance surgical precision and potentially reduce recurrence rates. By bridging the gap between diagnostic imaging and surgical intervention, Mascioni’s research represents a significant step toward personalized, image-guided cancer surgery. His work has the potential to transform standard of care for prostate cancer patients, offering surgeons a powerful tool to identify and remove malignant tissue more accurately.