James V. Belcastro
Papers
2
Total Citations
171
H-Index
2
About
James V. Belcastro is a pharmaceutical scientist whose research has made significant contributions to drug discovery and development, particularly in the area of metabolic stability assessment and high-throughput screening methodologies. His work focuses on developing automated analytical processes that streamline the early-stage evaluation of drug candidates, helping pharmaceutical researchers more efficiently identify promising compounds. Belcastro's most influential contribution is his 2008 paper describing an automated liquid chromatography-mass spectrometry (LC-MS) process for determining metabolic stability half-life and intrinsic clearance through substrate depletion, which has garnered 134 citations and become a key reference in pharmaceutical profiling workflows. Building on this, his earlier 2007 work introduced the MetFast assay — a high-throughput automated process for assessing microsomal cytochrome P450-mediated metabolic stability — further cementing his role in advancing rapid, reliable drug candidate screening. By integrating robotic liquid handling with sophisticated analytical techniques, Belcastro helped transform how pharmaceutical laboratories evaluate first-pass metabolism, reducing time and resource costs in early drug development. His methodologies continue to influence researchers working at the intersection of analytical chemistry, pharmacokinetics, and pharmaceutical sciences, making him a notable figure in the field of drug metabolism and disposition research.
Research Focus
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Top Papers
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