Dieter M. Drexler
Papers
2
Total Citations
171
H-Index
2
About
Dieter M. Drexler is a pharmaceutical scientist whose research has made significant contributions to drug metabolism and pharmacokinetics, with a particular focus on developing automated analytical workflows to accelerate early-stage drug discovery. His work centers on leveraging liquid chromatography-mass spectrometry (LC-MS) technologies to efficiently characterize the metabolic properties of drug candidates, a critical step in evaluating their viability as therapeutics. Drexler is perhaps best known for his development and refinement of automated high-throughput assays for assessing in vitro metabolic stability. His 2008 paper describing an automated LC-MS process for determining metabolic stability half-life and intrinsic clearance via substrate depletion has garnered 134 citations, establishing it as a foundational reference in pharmaceutical profiling. His earlier 2007 work introducing the MetFast assay — a streamlined approach to evaluating microsomal cytochrome P450-mediated first-pass metabolism — further cemented his reputation as an innovator in this space. By enabling faster, more reliable metabolic assessments using robotic liquid handlers and advanced mass spectrometry, Drexler's contributions have helped pharmaceutical researchers make better-informed decisions earlier in the drug development pipeline, ultimately improving the efficiency and success rates of candidate selection.
Research Focus
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Top Papers
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