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About

Jacqueline Naylor is a pioneering electrophysiologist whose work has transformed the study of ion channels in native and primary mammalian cells. Her key research areas include automated patch-clamp technology, cellular electrophysiology, and drug discovery. Naylor’s major contribution is the development of robotic multiwell planar patch-clamp systems, which enable high-throughput, parallel recording of ion channel activity from difficult-to-culture cells—a breakthrough that bridges the gap between traditional manual patch-clamp and industrial-scale screening. Her most-cited paper, "Robotic multiwell planar patch-clamp for native and primary mammalian cells" (2009, 108 citations), demonstrates this innovation, offering a robust platform for studying disease-relevant channels in their native environment. This work has had a profound impact, accelerating the discovery of new therapeutics for neurological and cardiac disorders by allowing researchers to test compounds on primary cells with unprecedented efficiency. Naylor’s achievements have established her as a leader in automated electrophysiology, and her methods are now standard in both academic labs and pharmaceutical industry settings, making her a key figure in modern ion channel research.