Isaac Wasserman
Mount Sinai Health System, Icahn School of Medicine at Mount Sinai
Papers
3
Total Citations
29
H-Index
2
About
Isaac Wasserman is a head and neck surgical oncologist whose research focuses on refining treatment paradigms for oropharyngeal cancer, particularly in the era of human papillomavirus (HPV)-related disease. His major contributions center on redefining risk stratification for contralateral cervical nodal involvement in early-stage HPV-positive oropharyngeal squamous cell carcinoma (OPSCC), challenging traditional assumptions about the extent of surgery and radiation needed. Through pathologic studies of patients undergoing bilateral neck dissection, Wasserman has identified key risk factors that help clinicians avoid overtreatment while maintaining oncologic safety—a critical advance given the young, otherwise healthy patient population affected by HPV-driven cancers. His work also explores the role of trimodality therapy (surgery, radiation, and chemotherapy) in the transoral robotic surgery (TORS) era, investigating which patient cohorts may benefit from this aggressive approach versus experiencing unnecessary toxicity. With his most cited papers accumulating 14 and 13 citations respectively, Wasserman’s research has direct clinical implications for de-escalation strategies and personalized treatment planning. His findings are shaping how surgeons and radiation oncologists approach the contralateral neck, potentially reducing morbidity without compromising survival outcomes.
Research Focus
Key Achievements
Top Papers
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