Hironori Murakami

SPring-8, Japan Synchrotron Radiation Research Institute

Papers

Total Citations

H-Index

About

Hironori Murakami has pioneered transformative approaches to macromolecular crystallography at Japan's SPring-8 synchrotron, dramatically expanding access to structural biology. His landmark 2008 work on mail-in data collection systems (48 citations) revolutionized how researchers utilize beamlines—allowing scientists worldwide to ship crystals for remote diffraction experiments without ever visiting the facility. This innovation democratized synchrotron access, enabling high-throughput structural studies across laboratories lacking local beamline resources. More recently, Murakami has advanced *in situ* data collection and ligand-screening technologies (2022, 12 citations), developing methods to evaluate crystal quality directly in crystallization plates without cryocooling. This technique accelerates fragment-based drug discovery by enabling rapid, room-temperature screening of protein-ligand complexes. His work bridges the gap between crystallization and data collection, reducing sample handling and enabling real-time assessment of crystal diffraction properties. By automating and streamlining synchrotron workflows, Murakami's contributions have made SPring-8 one of the world's most user-accessible structural biology facilities, supporting thousands of experiments annually and fundamentally changing how the global structural biology community approaches synchrotron-based research.