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About

Gregorio Spagni is a leading thoracic surgeon whose research focuses on the surgical management of myasthenia gravis (MG), particularly in its most severe forms. His work has fundamentally shaped the understanding of when and how to intervene surgically in patients with thymomatous and generalized MG. Spagni’s major contributions include pioneering studies on the outcomes of robotic thymectomy, demonstrating its safety and efficacy even in advanced-stage patients, and critically evaluating the risk-benefit ratio of thymectomy in severe, life-threatening MG. His 2023 paper, "Thymectomy in severe generalized myasthenia gravis: is the game really worth the candle?" (7 citations), directly challenges conventional wisdom by investigating the high-risk postoperative period for patients with Myasthenia Gravis Foundation of America classes IV–V. More recently, his 2025 work on "Surgical and Neurological Outcomes in Robotic Thymectomy for Myasthenic Patients with Thymoma" (3 citations) provides crucial long-term data on a previously understudied population. By combining rigorous surgical technique with detailed neurological follow-up, Spagni’s research offers evidence-based guidance for clinicians facing complex decisions in MG care, making him a key voice in the field of thoracic surgery and neuromuscular disease.