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About

Federica Di Naro is a radiation oncologist whose research focuses on advancing precision radiotherapy for breast cancer, particularly through stereotactic radiosurgery and partial breast irradiation. Her most notable contribution is the phase II ROCK trial (NCT03520894), which investigated preoperative robotic radiosurgery for early breast cancer. This landmark study, published in 2022 with 29 citations, demonstrated the feasibility and safety of treating a well-defined tumor target before surgery, potentially reducing radiation exposure to healthy tissue and improving cosmetic outcomes. Di Naro’s work sits at the intersection of surgical oncology and radiation therapy, exploring how preoperative approaches can optimize treatment precision. Her research has implications for de-escalating breast cancer therapy while maintaining efficacy, a critical goal in modern oncology. By pioneering the use of robotic radiosurgery in the preoperative setting, she has contributed to a growing body of evidence supporting non-invasive, targeted radiation techniques. Her findings help shape clinical protocols for early-stage breast cancer patients, offering a promising alternative to conventional postoperative whole-breast irradiation. Di Naro’s work continues to influence the evolution of breast-conserving therapies.