Elizabeth A. Komives

Papers

Total Citations

100

H-Index

About

Elizabeth A. Komives is a pioneering structural biochemist whose research centers on protein dynamics, allostery, and protein-protein interactions, with a particular emphasis on the NF-κB signaling pathway. Her major contributions lie in advancing hydrogen-deuterium exchange mass spectrometry (HDX-MS) as a powerful tool to probe protein folding, conformational changes, and allosteric communication. She developed DECA, a comprehensive, automatic post-processing program for HDX-MS data (2019, 60 citations), which has become an essential resource for the community, enabling high-throughput, reproducible analysis of large datasets. Her work has illuminated how dynamic allostery governs critical biological processes, such as the regulation of transcription factors. With over 40 citations for her 2018 review on HDX-MS revealing folding and allostery in protein-protein interactions, her impact is evident in both methodology and biological insight. Komives’ achievements include pioneering the use of HDX-MS to map protein-ligand interfaces and uncover hidden allosteric networks, making her a leading voice in the integration of mass spectrometry with structural biology. Her research continues to inspire students and researchers exploring the dynamic nature of proteins.