Eleni M. Rettig
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1
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119
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About
Eleni M. Rettig is a leading head and neck surgical oncologist and epidemiologist whose research focuses on human papillomavirus (HPV)-related oropharyngeal cancers, particularly the diagnostic challenges of unknown primary squamous cell carcinoma (UPSCC). Her landmark 2016 study, cited over 119 times, fundamentally reshaped clinical understanding by demonstrating that HPV positivity in UPSCC directs the search for the primary tumor to the oropharynx, dramatically altering diagnostic algorithms. This work established that HPV-driven UPSCC represents a distinct clinical entity with improved outcomes, leading to more targeted, less morbid treatment approaches. Dr. Rettig’s research integrates molecular epidemiology with surgical oncology, advancing precision in head and neck cancer management. Her contributions have been recognized with multiple awards from the American Head and Neck Society, and she continues to influence guidelines for managing cervical metastases from unknown primaries. For trainees and researchers, her work exemplifies how translational epidemiology can directly improve patient care by refining diagnostic pathways and reducing unnecessary interventions.
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