Douglas J. MacNeil

Merck & Co., Inc., Rahway, NJ, USA (United States)

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Total Citations

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About

Douglas J. MacNeil is a researcher whose work centers on mitochondrial biology and metabolic health, with a particular focus on developing tools to understand mitochondrial dysfunction in disease. His key contributions include the creation of a miniaturized, homogenous assay for measuring mitochondrial membrane potential, a critical indicator of organelle health. This assay, detailed in his 2011 paper, has been cited 6 times and provides a scalable method for studying mitochondrial function in conditions like Parkinson’s, Alzheimer’s, type 2 diabetes, and sarcopenia. By enabling high-throughput screening, MacNeil’s work has advanced the ability to investigate how mitochondrial dysfunction contributes to these age-related and metabolic diseases. His research underscores the importance of mitochondrial integrity in cellular energy production and disease pathogenesis, offering a foundation for future therapeutic strategies. MacNeil’s contributions are particularly valuable for researchers exploring the intersection of bioenergetics and chronic disease, highlighting his role in bridging assay development with translational insights.