Donald M. Engelman
Papers
1
Total Citations
8
H-Index
1
About
Donald M. Engelman is a pioneering biophysicist whose research centers on membrane protein structure, function, and the development of pH-sensitive targeting technologies. He is best known for his foundational work on the pH Low Insertion Peptide (pHLIP) technology, which exploits tumor acidity as a biomarker for targeted drug delivery. His major contributions include elucidating how pHLIPs insert into cell membranes in acidic environments, enabling the selective delivery of therapeutic and imaging agents to cancer cells. This innovation has profound implications for cancer diagnosis and treatment, as demonstrated in his 2022 study on targeting bladder urothelial carcinoma with pHLIP-ICG and pHLIP-amanitin. While this specific paper has garnered 8 citations, Engelman’s broader body of work—including seminal studies on bacteriorhodopsin and membrane protein folding—has amassed over 20,000 citations, reflecting his enduring impact. A member of the National Academy of Sciences, Engelman has also contributed to the development of the "two-stage model" of membrane protein folding, a cornerstone of the field. His work continues to inspire advances in targeted cancer therapy and molecular imaging.
Research Focus
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Top Papers
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