Domenico Tortorella
Papers
1
Total Citations
27
H-Index
1
About
Domenico Tortorella is a leading virologist whose research focuses on the molecular mechanisms of human cytomegalovirus (CMV) infection and immune evasion. His major contributions center on understanding the viral envelope glycoprotein complexes that govern CMV’s broad cellular tropism and persistence. In his highly cited 2016 work, Tortorella conducted a functional screen for anti-CMV biologics, identifying a broadly neutralizing epitope on the essential envelope protein complex gH/gL/gO (gH-trimer). This discovery illuminated a critical vulnerability in the virus, demonstrating that targeting this epitope can block infection across all cell types. With over 27 citations, this study has significantly advanced the development of antibody-based therapies and vaccines against CMV, a major pathogen in immunocompromised patients and newborns. Tortorella’s work is notable for bridging fundamental virology with translational medicine, providing a blueprint for rational vaccine design. His research continues to shape our understanding of viral entry and immune escape, making him a key figure in the fight against herpesvirus infections.
Research Focus
Key Achievements
Top Papers
- 1