Derek Smith
Papers
1
Total Citations
143
H-Index
1
About
Derek Smith is a leading figure in quantitative proteomics, best known for advancing the SISCAPA (Stable Isotope Standards and Capture by Anti-Peptide Antibodies) methodology. His work focuses on the precise measurement of proteins in complex biological fluids, particularly human plasma. Smith’s major contribution lies in simplifying and automating the SISCAPA workflow, making it more accessible for clinical applications. His highly cited 2009 paper (143 citations) introduced a streamlined protocol using magnetic beads and a novel rotary bead trap device, enabling efficient, specific capture of target peptides from whole plasma digests. This innovation dramatically improved the reproducibility and throughput of targeted protein quantification. By bridging the gap between antibody-based enrichment and mass spectrometry, Smith’s research has paved the way for robust biomarker verification and clinical assays. His work is foundational for researchers seeking to translate proteomic discoveries into reliable diagnostic tools, demonstrating how clever engineering of sample preparation can solve long-standing challenges in analytical chemistry.
Research Focus
Key Achievements
Top Papers
- 1SISCAPA Peptide Enrichment on Magnetic Beads Using an In-line Bead Trap Device143 citations · 2009