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David W. Schaal is a pioneering researcher in the field of stereotactic radiosurgery (SRS), with a focus on expanding its applications beyond traditional intracranial targets. His key research areas include image-guided radiosurgery, frameless treatment planning, and the management of trigeminal neuralgia. Schaal’s major contributions center on demonstrating the feasibility and efficacy of using the CyberKnife system—a frameless, image-guided platform—for both intra- and extra-cranial lesions. His 2006 paper on image-guided radiosurgical ablation (50 citations) laid foundational groundwork for treating lesions outside the head, overcoming the limitations of rigid frame-based systems. Additionally, his work on CT cisternography and non-isocentric planning for trigeminal neuralgia (29 citations) provided early clinical evidence that frameless radiosurgery could match the effectiveness of traditional frame-based rhizotomy, offering patients a less invasive option. Schaal’s research has directly influenced the adoption of CyberKnife technology in radiosurgery, enhancing precision and patient comfort. His achievements include pioneering non-isocentric planning techniques that improve dose conformity and reduce treatment toxicity. With over 80 combined citations, Schaal’s work remains a cornerstone for clinicians and researchers advancing stereotactic radiosurgery.