Craig K. Colton
Papers
1
Total Citations
504
H-Index
1
About
Craig K. Colton has made foundational contributions to our understanding of transient receptor potential (TRP) channels, particularly the thermosensitive TRPV subfamily. His landmark 2004 study, cited over 500 times, revealed that 2-aminoethoxydiphenyl borate (2-APB) acts as a common activator of TRPV1, TRPV2, and TRPV3—a surprising finding that transformed the field by identifying a shared pharmacological tool for probing these heat-activated channels. This work not only clarified the functional properties of TRPV channels but also provided a critical reagent for dissecting their roles in pain, thermosensation, and inflammation. Colton’s research has been instrumental in mapping the molecular architecture of TRP channels, bridging structural biology with physiological function. His studies are widely cited by neuroscientists and pharmacologists exploring sensory transduction and ion channel modulation. Through his rigorous electrophysiological and biochemical approaches, Colton has helped establish TRPV channels as key targets for therapeutic intervention in chronic pain and sensory disorders, cementing his reputation as a leading figure in ion channel research.
Research Focus
Key Achievements
Top Papers
- 12-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3504 citations · 2004