Courtney Mankus
Papers
1
Total Citations
134
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1
About
Courtney Mankus is a leading researcher in respiratory toxicology, specializing in the development of physiologically relevant in vitro models for assessing aerosol exposure. Her major contributions center on creating advanced 3D reconstructed human airway tissue systems that more accurately mimic the human respiratory tract than traditional animal models. In her seminal 2015 work, which has garnered 134 citations, Mankus pioneered an acute in vitro MTT cytotoxicity assay specifically designed to evaluate the potential irritant effects of e-cigarette aerosols. This method represents a critical advancement in regulatory toxicology, providing a standardized, ethical, and human-relevant approach for analyzing the respiratory impact of emerging nicotine delivery products. By optimizing these 3D tissue models for aerosol exposure, Mankus has established a foundational platform for the safety assessment of inhaled substances, enabling researchers to detect cytotoxic effects with greater precision. Her work directly addresses the urgent need for reliable test methods in the rapidly evolving landscape of e-cigarette research, making her a key figure in the transition toward non-animal testing alternatives for respiratory toxicity.
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