Clark M. Henderson
Papers
1
Total Citations
5
H-Index
1
About
Clark M. Henderson has made significant contributions to advancing high-throughput proteomics through innovations in nanoflow liquid chromatography (LC). His key research areas include analytical chemistry, separation science, and bioanalytical instrumentation. Henderson’s most notable work, "Automated Trapping Column Exchanger for High-Throughput Nanoflow Liquid Chromatography" (2017, 5 citations), addresses a critical bottleneck in nanoflow HPLC: instrument failure from fitting fatigue and trapping column degradation, which historically limited throughput. By designing an automated system to exchange trapping columns without manual intervention, he dramatically improved the robustness and speed of nanoflow LC, enabling more reliable, high-sensitivity analyses for complex biological samples. This innovation directly enhances detection limits and sensitivity—hallmarks of nanoflow techniques—while overcoming their practical limitations. Though his citation count is modest, Henderson’s work represents a practical engineering achievement that supports the broader adoption of nanoflow LC in proteomics and biomarker discovery. His contributions are particularly valuable for researchers seeking to scale up sensitive LC-MS workflows without sacrificing reliability.
Research Focus
Key Achievements
Top Papers
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