Christoph Bieniossek

Unit of Virus Host Cell Interactions, Université Grenoble Alpes, ETH Zurich

Papers

Total Citations

335

H-Index

About

Christoph Bieniossek is a leading figure in structural biology and recombinant protein production, with a particular focus on enabling the expression of multi-protein complexes. His work has fundamentally advanced the tools available for producing challenging eukaryotic protein assemblies, which are critical for structural and functional studies. Bieniossek is best known for pioneering new baculovirus expression systems, most notably detailed in his highly cited 2010 paper (220 citations), which provided robust solutions for producing recombinant protein complexes. He further expanded the field’s toolkit through his work on automated, high-throughput pipelines and polyprotein strategies for both prokaryotic and eukaryotic hosts (105 citations), streamlining the path from gene to structure. His research, including efforts toward “eukaryotic structural complexomics,” has had a lasting impact on how laboratories approach the expression of large, multi-subunit complexes, making him a key contributor to modern structural biology and biotechnology.