Christophe Romier
Institut de génétique et de biologie moléculaire et cellulaire
Papers
1
Total Citations
105
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About
Christophe Romier is a leading structural biologist whose research focuses on the molecular mechanisms of gene regulation, particularly through the lens of multiprotein complex assembly and function. His major contributions lie in developing and applying advanced structural and biochemical tools to decipher the architecture of transcription factor complexes, notably those involved in chromatin remodeling and RNA polymerase II-mediated transcription. Romier is perhaps best known for his pioneering work on multiprotein expression systems, as exemplified by his highly cited 2011 paper "Robots, pipelines, polyproteins: Enabling multiprotein expression in prokaryotic and eukaryotic cells" (105 citations), which provided a transformative platform for producing large, biologically relevant protein assemblies for structural studies. His research has yielded high-resolution structures of key regulatory complexes, including the SAGA coactivator and the INO80 chromatin remodeler, offering unprecedented insights into how these molecular machines control gene expression. With a career spanning over two decades, Romier’s work has been instrumental in bridging the gap between in vitro biochemistry and cellular function, earning him recognition as a leader in integrative structural biology. His findings continue to inform our understanding of transcriptional regulation, with direct implications for diseases linked to misregulated gene expression.
Research Focus
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Top Papers
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